How long does Tramadol stay in your urine? As you know that, Tramadol, which has Ultram as the brand name, is a synthetic drug. FDA approved the drug to test moderate and severe pain. It is available in the market since 1995 as the immediate-release drug. In 2005, it came out with the extended-release version. Tramadol is a unique drug. It is because Tramadol can give some impacts to the spectrum of the neurotransmitters. Also, it releases enkephalins and beta-endorphin to support analgesic effects since it acts as the mu-opioid receptor.
On the other hands, this receptor is also able to make the neurophysiological relaxations higher than before. Therefore, those who took Tramadol may feel better. At the same time, they can reduce their anxiety. Other than that, Tramadol can increase serotonin. Because of the complex mechanism, Tramadol is the promising pain treatment.
Nevertheless, there is some discomfort to deal with its side effects such as nausea, itchiness, and constipation. In addition, you should aware of using it for a long-term. This kind of usage can lose the efficacy because of the tolerance. Here, you should quit the drug. If you wonder how long does Tramadol stay in your urine after stop taking it, we give you all here.
How Long Does Tramadol Stay In Your Urine After Stopping
It sounds like a big thing if you have stopped taking Tramadol. It was not easy because you have dealt with the withdrawal symptoms. In fact, you may experience the discontinuation symptoms. Many people have to deal with it, especially those who have taken Tramadol for quite long. Meanwhile, it is good to know that each individual has automatic detoxify in their body. It works once they can leave Tramadol from their body.
How long does Tramadol stay in your urine and body system after stopping? Nevertheless, it is important to know about the elimination half-life first. The elimination half-life first is the time for our body to remove 50% of the drug from our urine. In fact, medical literature state that the elimination half-life of Tramadol is 6.3 hours.
Here, you can estimate that Tramadol can stay in your system for 1.44 days. Your body can remove Tramadol out of the system, including urine within 48 hours. It can happen after you took the last administration. However, you should know that the primary metabolite (o-desmethylTramadol), known as M1, has the longer half-life, which is 7.4 hours. So, the complete elimination of Tramadol including the metabolite that our body can do takes 1.7 days.
Several Factors To Determine Tramadol Clearance Through Your Urine
How Long Does Tramadol Stay In Your Urine? Well, it also depends on several factors. Not all people can eliminate Tramadol from their body in just 1.7 days. In fact, you may need more than 2 days. It is because of some factors such as the dosage and the term of administration. Other than that, it can be because of the co-ingestion of some drugs and the individual.
Besides, the food you consumed cannot impact the elimination half-life. However, you can increase the clearance speed. To do so, you should have a significant fluid intake. The fluid intake will improve the urinary flow rate to deal with the clearance.
Other than that, you should also know about your urinary pH. In most cases, the body system can eliminate Tramadol through the urinary excretion in the form of metabolites. According to some research, the urinary pH can determine the urinary drug clearance. It means greater alkalinity in urine makes longer excretion.
In fact, alkaline urine can promote the reabsorption of the metabolites with the help of your kidneys. As a result, it creates recirculation throughout your system. For this reason, the half-life can increase extensively, especially if you have a high level of alkaline diet. On the contrary, those with the acidic urine can excrete Tramadol’s metabolites effectively.
Tramadol And Ultram Details: Absorption, Metabolism, And Excretion
The gastrointestinal (GI) tract is the one that absorbs the administration of Tramadol in an extensive way. The research estimated that a 100 mg of the oral dose has 75% of bioavailability. Besides, how long does Tramadol stay in your urine is also about the peak plasma concretion, including its metabolite. It can appear 1.5 to 3 hours of post-administration in adults with good health. After that, the body system will distribute the drug with 20% of the dose binds to the plasma proteins.
How Long Does Tramadol Stay In Your Urine? For immediate-release version (IR), Tramadol will stay in your body for two days after the administration. Meanwhile, the four days is the common period for the extended-release version (ER) to stay in your body. Because it has lipophilic properties, commonly Tramadol can accumulate in the tissues.
The accumulation then continues to increase by the time, especially if you take a higher level of doses. Once the gastrointestinal tract absorbed the drug, the extensive metabolic process starts in the liver. Consequently, the metabolic process can convert Tramadol to metabolites with the use of enzymes. The process keeps going with the secondary metabolism done by some enzymes. Finally, the kidneys have an important role to process Tramadol and those metabolites to remove them through urine.
Based on the research, 60% of the Tramadol dose shows up as metabolites in the urine. However, the remaining 30% is still in the form of the unchanged Tramadol. In the end, your body needs 6.3 hours as the half-life of Tramadol. Meanwhile, it removes metabolite at 7.4 hours. Hence, how long does Tramadol stay in your urine is two days.
All about Urine Test For Tramadol
You cannot detect Tramadol through the standard drug screening (SAMHSA-5 panel). However, the advanced panel-screening test can detect it such as a toxicology screening specially designed to detect Tramadol. These tests are the urine test, hair test, saliva test, and the rare test is a blood test.
Before doing the urine test, it is important to know how long does Tramadol stay in your urine. In the urine test, you need to provide a fresh urine. It will be the sample form to detect the presence of Tramadol. After you collected the sample, you should send it to the laboratory. Inside the laboratory, the administrators will analyze your urine by using gas chromatography or mass spectrometry (GC/MS). This is important to detect unchanged Tramadol. In fact, Tramadol and the metabolites can appear in the urine test within two hours of ingestion.
How Long Does Tramadol Stay In Your Urine? Tramadol and the metabolites are still detectable for more than 40 hours after the use of the threshold, 12.5 pg. It happens if your body excretes Tramadol at the average rate. It means that it can leave your body through your urine in two days. Here, your body needs three to four days to remove Tramadol and its metabolites. This point is important to know if you used Tramadol at a high level of dose for a long-term.
Moreover, urine tests and hair tests are the less invasive option. However, both of them can provide the longer detection of Tramadol compared to the blood tests.
False-Positive In Urine Tests
Tramadol can create a false positive on the use of a PCP (phencyclidine). It sounds surprising when you see the positive result of having the urine-screening test. Well, it is true that the false positive on PCP through the urine test is a rare case. Nevertheless, it is possible to happen. Therefore, if you never took PCP, you should be aware of this problem. On the other hands, test positive for it if you have prescribed Tramadol to take.
How Long Does Tramadol Stay In Your Urine And How To Remove It
At this point, you have found some new facts about how long does Tramadol stay in your urine. Probably, you are one of those people who want to clear Tramadol completely from your body system. Basically, you can clear Tramadol and its metabolites through your urine as quickly as possible.
First of all, you should concern about the hydration. Remember that the liver has an important role to support the metabolic process to handle Tramadol dose. After that, your kidneys will continue the process. The final process of the elimination is through your urine. Therefore, it is good to have a concern about hydration so that you have a high level of urinary flows.
Those with a high level of urinary flow rate are possible to do quicker clearance and excretions. It also happens for all kinds of drugs. Therefore, if you really want to remove Tramadol, you should drink plenty of water. Supporting the optimal urinary flow rate is what you should concern about.
Besides, you need to know more about acidifying urine. Of course, there is a connection between urinary flow rate and acidify urine. So, if you want to increase the urinary flow rate through hydration, you should acidify your urine. What is more is that those with the high level of urinary pH (alkaline urine) have slower excretion than low urinary pH (acidic urine). Nevertheless, it is possible for you to improve the acidity of the urine through your diet. Therefore, it is better for you to eat foods like grains, meats, cranberries, and others. But, you better not to go overboard with the acidification since it can lead to acidosis.
In conclusion, most people excrete Tramadol less than 1.5 days. They also need less than 2 days to remove its metabolite after the final dose. Those are all things you should know about how long does Tramadol stay in your urine.
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