Tramadol is the synthetic opioid analgesic. It is used to deal with severe pain. Some Tramadol brands are Rybix, Ryzolt, Ultram, and others. Understanding How Long Does Tramadol Stay In Your System is important. It helps you understand the precautions to prevent the possible overdose and the drug interaction. If you are going to use it for children, we recommend consulting your doctor.
Tramadol works on the pain receptors, in the brain, and in the central nervous system. Tramadol also inhibits the re-uptake of serotonin and norepinephrine. Speaking more about Tramadol, it is the common option to provide the pain relief. The effect will start an hour after a dose and the peak is in two to four hours. Besides, Tramadol is available in the extended relief options.
How long does Tramadol stay in your body, especially for the extended options? Of course, this version has the longer period to show the effect in your body. It means that this version can stay longer in your system.
How Long Does Tramadol Stay In Your Body?
How Long Does Tramadol Stay In Your System especially your blood?
The half-life Tramadol can be there for about five to nine hours. If you take multiple doses, it can be longer than that. As of the complete elimination, the body system can remove it after five or six times of the half-life.
Before talking other things too far, it is important to know the definition of “half-life”. The University of Lausanne of Switzerland states the elimination of half-life is the time for the Plasma Concentration. We also can say the amount of the drug that our body can reduce by 50%.
Besides, it is not easy to determine “How Long Does Tramadol Stay In Your System”. It is also about the body mass, the metabolism, age, and physical activity. Tramadol may also remain at hydration level, health conditions, and others.
However, if we have to use the concept of elimination half-life, we can determine that the detectable Tramadol can stay in your body for about a day and a half. Well, it does not mean that our body is completely clean after that amount of time. Tramadol has a longest lasting component that is the primary metabolite, known as O-desmethylTramadol. This component can stay in your body for 7.4 hours more after your body has metabolized other components.
So, we can calculate that our body is completely clean from Tramadol after 1.7 days from the ingestion. Many researchers used this data under the controlled environments. For the true time about How Long Does Tramadol Stay In Your System can be vary depending on the different variables.
How Long Does Tramadol Stay In Your System Especially In Your Urine?
Tramadol is detectable for two to four days. Generally, it does not show up as the positive opiates on the drug test for instance for the employment test. On the other hand, Tramadol is detectable on the prescription drug-screening test. Therefore, you should disclose the prescription to the lab if you must take the urine drug test while taking Tramadol. This can help you interpret the results.
The Factors That Influence How Long Does Tramadol Stay In Your System
As we have already explained above that the O-desmethyl tramadol is the longest elements of Tramadol that exist in your system. Your system can clear it in less than 48 hours after the final dose, but it does not mean that others can do the same thing at the same period as you. Others may need longer than two days to fully remove the drug. It depends on some factors as below:
- Individual factors
For example, you and your friend took a single 50 mg of Tramadol at the same time. It is possible for your body system to excrete the drug faster compared to your friend. The individual factors can determine the length of the presence of Tramadol in the body systems, such as the body mass, the age, the genetics, and the hepatic functions.
How Long Does Tramadol Stay In Your System? It also depends on the dosage. If you go with the higher doses, it means that you are giving a greater burden on the hepatic isoenzymes to perform the metabolism. The isoenzymes must work harder for the excretion. That is why if you are taking a higher dose of the drug, for example, 300 mg a day, your body will metabolize it at the slower speed because of the increased amount. In addition, your body has to provide more metabolites to support the clearance compared to those who are taking Tramadol with a low dose.
We can say that going with a higher level of dose can reduce the metabolism and the excretion speed. Moreover, the higher doses provide greater accumulation of Tramadol in the body tissues. The research found that it is possible to increase the accumulation of Tramadol if you take higher doses.
- The Administration
How Long Does Tramadol Stay In Your System? it also depends on the administration. It can be the frequency to administer Tramadol and the duration of the administration. If you take immediate-release (IR) and use it when you only need it, likely the intermittent basis can excrete the drug faster than other who take extended-release (ER), for example, Tramadol once per day.
Meanwhile, if you are taking the ER format in less than four days, it is possible to excrete it faster than those who have been spending more than 4 days to take Tramadol.
- Using Tramadol with other drugs
If you take other drugs at the same time with Tramadol, it can alter the pharmacokinetics. If any drug interactions happen, it can affect the functionality and the elimination half-life. Therefore, it makes the metabolism is less efficient and the clearance process run improperly.
There are some drugs can interact with Tramadol, such as Cinacalcet, Prozac, Paxil, Ritonavir, and others. On the contrary, some drugs can support its clearance but many of us thought that it can reduce the metabolism or the excretion times, for example, Dexamethasone and Rifampicin.
Is Tramadol Addictive?
Tramadol can be addictive even though you picked the prescribed dose. Once you stop using it in a sudden, then you may feel the withdrawal symptoms. To prevent this happens to you, your doctor can help you arrange the schedule about the right time to stop using it.
It is important to note that liver will break down Tramadol. After that, the kidneys will work to excrete it in the urine. On the contrary, 7% of people have poor metabolism when they are dealing with Tramadol. In this condition, they have a more active drug in the blood screen for a quite longer. For these people, they have more risks if they also take any medications that reduce the performance of the enzymes to break down Tramadol.
How Many Tramadol You Can Take In A Day?
After understanding How Long Does Tramadol Stay In Your System, it is also important to know the amount of Tramadol you should take in a day. Before talking about it, it is essential to know that this is a prescribed medicine. You only get Tramadol if your doctor suggests it for you. You must follow the instruction of your doctor when you are consuming the tablets or the pills. Do not take more than the dose, do not take it more often, and do not take it for a longer period than what your doctor said.
In case that you think the medicine is not effective for your medication, do not increase the dose. It is better to visit your doctor. For the dose, what you should take can be different to others. It is important to follow the directions on the label or listen to the orders of your doctor. It means that if you find that your dose is different from the information below, do not change it before consulting your doctor.
In fact, the amount of the medicine to take depends on the strength of the medicine. The number of doses to take each day, the time between the doses and the length of the time to take Tramadol can be different for each patient. It is because doctor uses your medical problem before using the medicine. Here is the information you should know.
- Tramadol For Chronic Pain
If you are using the extended-release tablets, adults need 100 milligrams once a day at first. Your doctor may recommend more doses if necessary. The dose should not be up to 300 mg per day.
If you are using it for oral dosage form tablets, adults and teenagers between 16 years and older need 50 to 100 milligrams for every four to six hours if necessary, at first. Your doctor may suggest increasing the dose, but it should not be up to 400 milligrams per day. Meanwhile, children that are younger, the use and the dose of Tramadol is under the doctor’s supervision.
- Tramadol For Oral Dosage Form (Tablets)
For adults and teenagers 16 years and older, they can take 25 milligrams per day at first, for every morning. Your doctor may recommend increasing the dose if necessary. On the contrary, the dose should not be up to 400 mg per day. Meanwhile, children younger than 16 years of age only can use Tramadol and the dose is under the control of the doctor.
In case that you forget and miss a dose of Tramadol, it is better to take it as soon as possible. However, if the time is closer to the next dose, you can skip the missed dose and then go back to the regular dosing schedule. It is important not to double doses.
The Effects Of Taking Tramadol Too Much
While it stays in your system, Tramadol can depress breathing. It is also the main reason that your pupils are constricting. Tramadol also has a big impact on your digestive system. It decreases mobility in the digestive system so that the system digests food longer.
If you take Tramadol, it may cause constipation. Other than that, Tramadol dilates your blood vessels. Taking Tramadol may make you flushing, sweating, itching, red eyes, and dizziness. Even, you can feel faintness when you are going to get up after lying down for a quite long. If your body is tolerant to Tramadol already, it is possible to take more safely. However, you should know the guideline so that you can take Tramadol safely.
If you take 500 mg of Tramadol, you may experience some side effects, including seizures. The overdose will not occur if you are not taking between 2.65 grams and 8.2 grams. If you take 500 mg of Tramadol, likely you will end up in the hospital. However, it does not kill you yet.
For the opiate naïve patients, a doctor may start with a 25 mg at a time. Your doctor does not suggest it more than 100 mg per day. This is important to prevent the potential side effects, instead of avoiding the overdose.
However, if you are opiate tolerant patients, you may increase the dosage. We suggest you not taking more Tramadol without consulting our doctor. Your doctors can increase the doses to support the patient tolerance, and the maximum recommended a daily dosage of Tramadol for this patient is 450 mg.
How Long Does Tramadol Stay In Your System and Can It Kill You?
It is the rule to take the amount of the prescribed Tramadol based on the schedule. It is also important to prevent the overdose. You may though that crushing or cutting the extended relief capsules or tablets are the effective solution to reduce the dose. But, this is a wrong perception. When you do this, it will only release the larger dose.
Moreover, Tramadol interacts with many medications. You should be cautious because it can lead to life-threatening interactions. If it happens to you, you may experience sedation, breathing, and even coma. Tramadol can be dangerous if it interacts with Alcohol, Monoamine oxidase inhibitors (MAOI), and benzodiazepines. Therefore, we suggest you discuss the medications you take, medications you are going to take, and medications you are going to stop with your doctor. He can screen and adjust everything to prevent any dangerous impact due to the interactions.
While you are taking Tramadol, you must not do the following things:
- Drink alcohol
- Taking medication that contains alcohol
- Use street drugs
Otherwise, the life-threatening interactions are possible to happen and this leads to a serious condition. The symptoms of Tramadol overdose are below:
- Decreased size of the pupil’s eye
- Difficult to breathe
- Slowed heartbeat
- Muscle weakness
- Cold and clammy skin
In addition, the unintentional Tramadol overdose can happen. It means that you do not get enough pain relief from the prescribed dose after using it for an extended period. After that, your body starts developing the tolerance to Tramadol. When you increase the frequency to take Tramadol, it can bring the unintentional Tramadol overdose. Other than that, Tramadol may make you feel “high”. It happens due to the unintentional Tramadol overdose that likely happens if you take larger amounts of Tramadol than the prescribed. The most important is when you chew, crush, inject or snort Tramadol pills, you much more likely get the overdose. This condition can increase the risk of death. If you take this medication, you should only swallow Tramadol as the whole pill and follow the recommended dose from your doctor.
The overdose can stop your breath completely if there is Tramadol overdose complication. Here, you should understand that when you are consuming certain medicines, these should tolerate the presence of Tramadol.
In the end, we can say that Tramadol is a pain reliever that is like a narcotic. We use it to treat moderate and severe pain. Besides, you should not use Tramadol if you have severe breathing problems, a stomach blockage, intestines, or if you used alcohol recently, including sedatives, narcotic medication, tranquilizers and the MAO inhibitor.
It is more than just How Long Does Tramadol Stay In Your System, but there are some potential risks are waiting for you. In fact, Tramadol can slow and even stop your breathing. If it does not happen to you, it may create habit-forming. If you are misusing this medicine, it can give you some effects such as addiction, overdose, and even death. You should not use it carelessly for a child or other people if there is no prescription.
The most important thing to know is that Tramadol is not for children less than 12 years old. Some people who took this medicine showed they experienced seizures. It can happen if you have a history of head injury or seizures, metabolic disorder or you are taking certain medicines, such as muscle relaxers, antidepressants, medicine for nausea and vomiting, as well as narcotics.
How Long Does Tramadol Stay In Your System While Pregnancy And Breastfeeding?
How Long Does Tramadol Stay In Your System while pregnancy is hard to ignore? In fact, if you are pregnant and you take Tramadol, it can lead to life-threatening withdrawal symptoms. The risk goes to the newborn. The fatal side effects may happen if you are taking Tramadol with alcohol as well as other drugs that contain alcohol. When you do it, it can cause drowsiness and the slowed breathing.
Tramadol also interacts with many drugs that can lead to dangerous side effects or even death. You should tell your doctor about your current medicines that you are going to start or stop.
When you are breastfeeding, do not take Tramadol. This medicine passes into the breast milk that can cause drowsiness, breathing issues, and death in a baby.
What Helps Withdraw Off Tramadol?
After taking Tramadol, many of us want to make sure that our body is completely clean from it. It is more than just understanding How Long Does Tramadol Stay In Your System.
Below, we provide you some tips on how to support the clearance of Tramadol after stopping it. Make sure that you verify the safety and the efficacy of these tips with your doctor.
- Complete Cessation
It means that you are going to stop using Tramadol permanently. It is something tough to do, especially if you have been implementing it for a long time. On the contrary, it is a must to have complete cessation. You can use this way to make sure that your body is clean from it completely. Keep in mind that the sooner you stop using Tramadol, the faster your body can excrete it.
- Burn Your Body Fat
It is important to know that Tramadol is a lipophilic drug. In another word, it can bind to fat stores to the entire of your body. When Tramadol accumulates significantly within your system, you will have a high body fat percentage. Therefore, the best way to deal with the accumulation is to burn the body fat. This is important to purge the fat stores from the accumulation. It also helps the detoxification faster.
- Maintain Hydration
The liver is the place to metabolize most of the Tramadol dose. After that, the process will keep going in the kidneys. The final process is when your body eliminates it via urine. It is good to maintain hydration because it makes your urinary flow rate increases. With the high urinary flow rate, it supports the faster clearance speed. It is good to offer fast excretion of many drugs. Therefore, it is good for you to drink plenty of water. It can help you to have an optimal urinary flow rate.
- Acidify Urine
Not only increasing the urinary flow rate with the hydration, but you also can acidify your urine. If you have high urinary pH or alkaline urine, it means that your body excretes drugs slower. It is possible to increase the acidity of the urine by consuming foods such as grains, meats, and cranberries. It is important not to go overboard with the acidification because the result can be acidosis.
- Activated Charcoal
You can take activated charcoal to make sure that there is no unmetabolized Tramadol. It is possible if there are floating metabolites within your system. Activated charcoal can be the best supplements if you need antidepressant withdrawal. It can bind any toxic remnants in the gut and eliminate them from your body. If you have no idea about How Long Does Tramadol Stay In Your System, you can take activated charcoal. It helps the clearance.
- How Tramadol Acts in Your System
- Estimated Time The Body Excretes Tramadol
- How Long Has Tramadol Stayed In Your System
- Tramadol (Oral Route)
- Tramadol overdose: How much amount of tramadol to OD?
- Image: addictionresource.com, weedshome.com, linkedin.com, verywell.com, slideplayer.com